溃疡性结肠炎相关性坏疽性脓皮病与特发性坏疽性脓皮病的临床特征比较。
Comparison of Clinical Features between Pyoderma Gangrenosum Concomitant by Inflammatory Bowel Disease and Idiopathic Pyoderma Gangrenosum.
机构信息
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
出版信息
Chin Med J (Engl). 2017 Nov 20;130(22):2674-2679. doi: 10.4103/0366-6999.218004.
BACKGROUND
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is highly associated with inflammatory bowel disease (IBD). Certain PG patients with no systemic disorders have been diagnosed with idiopathic PG. This study sought to clarify the difference between PG with IBD and idiopathic PG based on clinical features, laboratory tests, and medications.
METHODS
Twelve patients with PG and IBD and 24 patients with idiopathic PG, who were hospitalized in Peking Union Medical College Hospital from 2000 to 2017, were retrospectively categorized into the IBD group and control group, respectively. Data of clinical features, laboratory tests, and medications were collected and compared between the two groups.
RESULTS
Both groups were similar with respect to their clinical features. However, the IBD group had an increased occurrence of arthralgia or arthritis (58.3% vs. 12.5%, P = 0.007), anemia (83.3% and 29.2%, P = 0.004), and an increased percentage of antineutrophilic cytoplasmic antibody (ANCA)-positive patients (85.7% and 0.0%, P < 0.001), compared to the control group.
CONCLUSION
PG patients with IBD had increased occurrence rates of arthralgia or arthritis, anemia, and ANCA-positive status compared to idiopathic PG patients.
背景
坏疽性脓皮病（PG）是一种罕见的中性粒细胞皮肤病，与炎症性肠病（IBD）高度相关。某些无系统性疾病的 PG 患者被诊断为特发性 PG。本研究旨在基于临床特征、实验室检查和药物治疗来阐明 IBD 相关 PG 与特发性 PG 之间的差异。
方法
回顾性分析 2000 年至 2017 年期间在北京协和医院住院的 12 例 IBD 相关 PG 患者和 24 例特发性 PG 患者，分别归入 IBD 组和对照组。收集并比较两组患者的临床特征、实验室检查和药物治疗数据。
结果
两组患者的临床特征相似。然而，与对照组相比，IBD 组患者更易出现关节痛或关节炎（58.3%比 12.5%，P = 0.007）、贫血（83.3%比 29.2%，P = 0.004）和抗中性粒细胞胞质抗体（ANCA）阳性率更高（85.7%比 0.0%，P < 0.001）。
结论
与特发性 PG 患者相比，IBD 相关 PG 患者更易出现关节痛或关节炎、贫血和 ANCA 阳性。
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