Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.
Drug Des Devel Ther. 2024 Oct 4;18:4427-4447. doi: 10.2147/DDDT.S477679. eCollection 2024.
Linn is a popular herbal remedy in many countries, and its activities have been studied through many studies, starting from in silico, in vitro, and in vivo. This narrative review will focus more on secondary metabolites that are responsible for certain pharmacological activities that have undergone in vivo, in vitro, and in silico testing to determine the underlying mechanism. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in . There have been numerous studies looking at the role of flavonoids about specific diseases, and flavonoid testing is quite thorough because it covers three different study types. However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, and antiviral can be carried out into further research. Additionally, several disorders lack comprehensive investigation, particularly in silico studies, therefore further study is required to fill any gaps in the knowledge.
林乃是许多国家流行的草药疗法，其活性已通过许多研究进行了研究，从计算机模拟、体外和体内研究开始。本叙述性评论将更多地关注负责某些已进行体内、体外和计算机模拟测试以确定潜在机制的药理学活性的次生代谢物。已经确定了二十种药理学活性，其中黄酮类化合物（大黄素、山奈酚、槲皮素）是最常见的次生代谢物。已经有许多研究探讨了黄酮类化合物在特定疾病中的作用，并且黄酮类化合物的测试非常彻底，因为它涵盖了三种不同的研究类型。然而，在评估剂型方面并没有取得重大进展，因此需要进行进一步的研究，以便对有前途的活性（如抗糖尿病、抗真菌和抗病毒）进行测试结果。此外，一些疾病缺乏全面的研究，特别是在计算机模拟研究方面，因此需要进一步研究以填补知识空白。
