Department of Chemistry, University of the Free State, Nelson Mandela Drive, Bloemfontein 9301, South Africa.
Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Chem Commun (Camb). 2024 Nov 26;60(95):14030-14033. doi: 10.1039/d4cc04245j.
The retention of the covalent binding of an organometalllic rhenium complex as a model for a technetium-99m imaging agent, to a protein at physiological body temperature 37 °C is described. Detailed structure comparisons are made to the related 100 K crystal structure. The generality of the need for this sort of analytical procedure for guiding ligand lead compound discovery is emphasised.
描述了一种锝-99m 成像剂模型的有机金属铼络合物在生理体温 37°C 下与蛋白质的共价键结合的保留情况。与相关的 100 K 晶体结构进行了详细的结构比较。强调了需要这种分析程序来指导配体先导化合物发现的普遍性。
