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上海光源大分子晶体学光束线站的现状。

Status of macromolecular crystallography beamlines at SSRF.

作者信息

Kong Huating, Zhou Huan, Xu Qin, Liu Ke, Zhang Kunhao, Wang Xingya, Wang Weiwei, Wang Zhijun, Wang Sisheng, Wang Yuzhu, Tang Lin, Yu Feng, He Jianhua, Wang Qisheng

机构信息

Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, People's Republic of China.

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, People's Republic of China.

出版信息

J Synchrotron Radiat. 2025 Jan 1;32(Pt 1):234-245. doi: 10.1107/S1600577524011597.

DOI:10.1107/S1600577524011597
PMID:39705252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11708842/
Abstract

Shanghai Synchrotron Radiation Facility (SSRF) is a third-generation 3.5 GeV synchrotron facility located on the Chinese mainland, operational for user applications since 2009. With the completion of its Phase II project this year, SSRF now supports over 40 experimental stations across various research fields. For the structural biology community, there are three macromolecular crystallography (MX) beamlines (BL02U1, BL17UM and BL10U2) and one endstation at the white X-ray beamline (BL03HB) managed by SSRF to meet the needs of both academic and industrial users seeking to determine macromolecular crystal structures. The MX group at SSRF is dedicated to continuously upgrading these beamlines in terms of technology and scientific capabilities. This paper reports on the current status of all the MX beamlines at SSRF and discusses emerging trends.

摘要

上海同步辐射装置（SSRF）是中国大陆的一台第三代3.5 GeV同步辐射装置，自2009年起投入用户应用。随着今年二期工程的完成，SSRF目前支持40多个跨不同研究领域的实验站。对于结构生物学界，SSRF管理着三条大分子晶体学（MX）光束线（BL02U1、BL17UM和BL10U2）以及一条位于白色X射线光束线（BL03HB）的终端站，以满足寻求确定大分子晶体结构的学术和工业用户的需求。SSRF的MX团队致力于在技术和科学能力方面不断升级这些光束线。本文报告了SSRF所有MX光束线的现状并讨论了新趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/ec6cc9a34c37/s-32-00234-fig17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/45d4dd8311bb/s-32-00234-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/c8a74da1edd3/s-32-00234-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/4f0f6f604bc8/s-32-00234-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/e01f75c9fbfb/s-32-00234-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/4e7adcaacc9a/s-32-00234-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/9e16dc1783ef/s-32-00234-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/7dfc511fef5b/s-32-00234-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/ccb1fbf9e94e/s-32-00234-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/e955756ca3a7/s-32-00234-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/95d7359b526d/s-32-00234-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/424eec2c8af3/s-32-00234-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/c6cf5d4dd82c/s-32-00234-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/3c628515a8d8/s-32-00234-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/f873a7c69a7e/s-32-00234-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/5cb11b4b58ba/s-32-00234-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/2601b7cd5d74/s-32-00234-fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/ec6cc9a34c37/s-32-00234-fig17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/45d4dd8311bb/s-32-00234-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/c8a74da1edd3/s-32-00234-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/4f0f6f604bc8/s-32-00234-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/e01f75c9fbfb/s-32-00234-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/4e7adcaacc9a/s-32-00234-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/9e16dc1783ef/s-32-00234-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/7dfc511fef5b/s-32-00234-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/ccb1fbf9e94e/s-32-00234-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/e955756ca3a7/s-32-00234-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/95d7359b526d/s-32-00234-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/424eec2c8af3/s-32-00234-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/c6cf5d4dd82c/s-32-00234-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/3c628515a8d8/s-32-00234-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/f873a7c69a7e/s-32-00234-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/5cb11b4b58ba/s-32-00234-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/2601b7cd5d74/s-32-00234-fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4e/11708842/ec6cc9a34c37/s-32-00234-fig17.jpg

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本文引用的文献

1
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Chem Commun (Camb). 2024 Nov 26;60(95):14030-14033. doi: 10.1039/d4cc04245j.
2
Structure-based reshaping of a new ketoreductase from Sphingobacterium siyangense SY1 toward α-haloacetophenones.基于结构的新型酮还原酶的重塑，来自鞘氨醇单胞菌SY1 对α-卤代苯乙酮。
Int J Biol Macromol. 2024 Oct;277(Pt 1):134157. doi: 10.1016/j.ijbiomac.2024.134157. Epub 2024 Jul 24.
3
Guide to serial synchrotron crystallography.
串行同步加速器晶体学指南。
Curr Res Struct Biol. 2024 Feb 6;7:100131. doi: 10.1016/j.crstbi.2024.100131. eCollection 2024.
4
Finback: a web-based data collection system at SSRF biological macromolecular crystallography beamlines.Finback：上海光源生物大分子晶体学光束线站基于网络的数据采集系统。
J Synchrotron Radiat. 2024 Mar 1;31(Pt 2):378-384. doi: 10.1107/S1600577523010615. Epub 2024 Jan 19.
5
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir.SARS-CoV-2 对奈玛特韦耐药的分子机制。
Nature. 2023 Oct;622(7982):376-382. doi: 10.1038/s41586-023-06609-0. Epub 2023 Sep 11.
6
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.人类 ACE2 与当前流行的奥密克戎 SARS-CoV-2 亚变种 BA.2 和 BA.1.1 更高结合亲和力的结构基础。
Cell. 2022 Aug 4;185(16):2952-2960.e10. doi: 10.1016/j.cell.2022.06.023. Epub 2022 Jun 16.
7
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8
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9
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Acta Crystallogr F Struct Biol Commun. 2021 Sep 1;77(Pt 9):319-327. doi: 10.1107/S2053230X21008104. Epub 2021 Aug 24.
10
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