Bosc E, Grolleau-Raoux R, Bertinchant J P
Arch Mal Coeur Vaiss. 1985 Oct;78(10):1552-7.
Multiple congenital coronary-left ventricular fistulae (CLVF) are rare (4.5% of all coronaro-cardiac fistulae, the same incidence as isolated CLVF); data obtained from 7 personal and 25 previously reported cases, showed that this anomaly, is diagnosed at coronary angiography performed for anginal chest pains in 2 out of 3 cases; cardiac auscultation was usually normal but the basal ECG was pathological in 3 out of 4 cases; the electrical changes suggested myocardial ischaemia in 20 out of 24 cases. However, exercise stress testing was negative in 47% of cases. Multiple CLVF usually arose from the same artery (59%); the commonest artery involved was the left anterior descending (84% of the single artery fistulae and 100% in cases of multiple CLVF arising from more than one artery). The angiographic appearances of multiple CLVF were constant: images of "intracavitary rain". Associated ventriculographic abnormalities were uncommon but coronary atherosclerosis was observed in 15% of cases. The main differential diagnosis is that of CLVF secondary to intra-left ventricular thrombosis due to the development of neovascularisation of the thrombus from the underlying endocardium. The value of non-invasive investigations (2D echocardiography alone or coupled with pulsed Doppler) has not been shown in this type of coronaro-cardiac fistulae. Surgical correction was attempted in 3 cases, 2 of which had associated cardiac pathology justifying surgery. The presence of unequivocal coronary insufficiency due to CLVF was not demonstrated despite some suggestive clinical and paraclinical indicators.
多发性先天性冠状动脉-左心室瘘(CLVF)较为罕见(占所有冠状动脉-心脏瘘的4.5%,与孤立性CLVF发病率相同);从7例个人病例和25例既往报道病例中获取的数据显示,该异常在3例中有2例是在因心绞痛进行冠状动脉造影时被诊断出来的;心脏听诊通常正常,但4例中有3例基础心电图存在异常;24例中有20例的电变化提示心肌缺血。然而,47%的病例运动负荷试验结果为阴性。多发性CLVF通常起源于同一动脉(59%);最常受累的动脉是左前降支(在单支动脉瘘中占84%,在起源于多支动脉的多发性CLVF病例中占100%)。多发性CLVF的血管造影表现具有一致性:呈“心腔内雨”样影像。相关的心室造影异常并不常见,但15%的病例观察到冠状动脉粥样硬化。主要鉴别诊断是继发于左心室内血栓形成的CLVF,这是由于血栓从心内膜下层发生新生血管化所致。在这类冠状动脉-心脏瘘中,尚未显示出非侵入性检查(单独的二维超声心动图或联合脉冲多普勒)的价值。3例尝试进行了手术矫正,其中2例伴有需要手术治疗的心脏病变。尽管有一些提示性的临床和辅助检查指标,但尚未证实CLVF导致明确的冠状动脉供血不足。