Revive & Restore, 1505 Bridgeway, Suite 203, Sausalito, CA 94965, USA.
Gamete Research Centre, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Development. 2024 Oct 15;151(20). doi: 10.1242/dev.203116. Epub 2024 Oct 9.
Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the origins and rules of life. However, the rapid decline in biodiversity reported recently foreshadows a potentially catastrophic collapse of many important ecosystems and the associated irreversible loss of many forms of life on our planet. Immediate action by conservationists of all stripes is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species.
野生动植物生物多样性对于健康、有弹性和可持续的生态系统至关重要。对于生物学家来说，这种多样性也代表了一个遗传、分子和发育机制的宝库，加深了我们对生命起源和规律的理解。然而，最近报告的生物多样性快速下降预示着许多重要生态系统可能会灾难性地崩溃，地球上许多生命形式也将不可逆转地消失。需要所有派别的自然资源保护主义者立即采取行动，以避免这场灾难。在本期特写中，我们汇集了最近由 Revive & Restore 主办的一次研讨会讨论的见解和建议，该研讨会聚集了专家讨论干细胞技术如何支持传统保护技术并帮助保护动物生物多样性。我们讨论了重编程、体外配子发生、疾病建模和胚胎建模，并强调了超越哺乳动物物种利用干细胞技术的前景。
