Istinye University, Department of Cardiology - İstanbul, Turkey.
Medical Park Hospital, Department of Cardiology - Antalya, Turkey.
Rev Assoc Med Bras (1992). 2024 Oct 7;70(10):e20240508. doi: 10.1590/1806-9282.20240508. eCollection 2024.
The aim of our study was to determine the role of serum glucose-potassium ratio in predicting inhospital mortality in coronary care unit patients.
This study used data from the MORtality in CORonary Care Units in Turkey study, a national, observational, multicenter study that included all patients admitted to coronary care units between September 1, 2022, and September 30, 2022. Statistical analyses assessed the independent predictors of mortality. Two models were created. Model 1 included age, history of heart failure, chronic kidney disease, hypertension, diabetes mellitus, and coronary artery disease. Model 2 included glucose-potassium ratio in addition to these variables. Multivariate regression and receiver operating characteristic analysis were performed to compare Model 1 and Model 2 to identify if the glucose-potassium ratio is an independent predictor of inhospital mortality.
In a study of 3,157 patients, the mortality rate was 4.3% (n=137). Age (p=0.002), female gender (p=0.004), mean blood pressure (p<0.001), serum creatinine (p<0.001), C-reactive protein (p=0.002), white blood cell (p=0.002), and glucose-potassium ratio (p<0.001) were identified as independent predictors of mortality through multivariate regression analysis. The receiver operating characteristic analysis indicated that Model 2 had a statistically higher area under the curve than Model 1 (area under the curve 0.842 vs area under the curve 0.835; p<0.001). A statistically significant correlation was found between the inhospital mortality and glucose-potassium ratio (OR 1.015, 95%CI 1.006-1.024, p<0.001).
Our study showed that the glucose-potassium ratio may be a significant predictor of inhospital mortality in coronary care unit patients.
本研究旨在确定血清葡萄糖-钾比值在预测冠心病监护病房患者住院死亡率中的作用。
本研究使用了来自土耳其全国观察性多中心冠心病监护病房死亡率研究的数据，该研究纳入了 2022 年 9 月 1 日至 9 月 30 日期间入住冠心病监护病房的所有患者。统计分析评估了死亡率的独立预测因素。建立了两个模型。模型 1 包括年龄、心力衰竭史、慢性肾脏病、高血压、糖尿病和冠状动脉疾病。模型 2 除了这些变量外还包括血糖-钾比值。进行多变量回归和受试者工作特征分析，以比较模型 1 和模型 2，确定血糖-钾比值是否是住院死亡率的独立预测因素。
在一项对 3157 名患者的研究中，死亡率为 4.3%（n=137）。年龄（p=0.002）、女性性别（p=0.004）、平均血压（p<0.001）、血清肌酐（p<0.001）、C 反应蛋白（p=0.002）、白细胞（p=0.002）和血糖-钾比值（p<0.001）通过多变量回归分析被确定为死亡率的独立预测因素。受试者工作特征分析表明，与模型 1 相比，模型 2 的曲线下面积具有统计学意义（曲线下面积 0.842 比曲线下面积 0.835；p<0.001）。住院死亡率与血糖-钾比值之间存在统计学显著相关性（比值比 1.015，95%置信区间 1.006-1.024，p<0.001）。
本研究表明，血糖-钾比值可能是冠心病监护病房患者住院死亡率的一个重要预测因素。
