Horrocks L A, Demediuk P, Saunders R D, Dugan L, Clendenon N R, Means E D, Anderson D K
Cent Nerv Syst Trauma. 1985 Summer;2(2):115-20. doi: 10.1089/cns.1985.2.115.
Spinal cord injury has been studied using a cat compression model. Very early changes in lipid metabolism were found that compromise the integrity of the plasma membrane and decrease the activities of ATPases. Up to 18% of the ethanolamine plasmalogens are lost, with very marked elevations of the free fatty acids, arachidonic acid, diacylglycerols, prostaglandins, thromboxanes, and leukotrienes. These changes result in edema, inflammation, necrosis of oligodendroglia, demyelination, and paralysis.
脊髓损伤已通过猫压缩模型进行研究。发现脂质代谢的早期变化会损害质膜的完整性并降低ATP酶的活性。高达18%的乙醇胺缩醛磷脂会丢失，同时游离脂肪酸、花生四烯酸、二酰基甘油、前列腺素、血栓素和白三烯会显著升高。这些变化会导致水肿、炎症、少突胶质细胞坏死、脱髓鞘和瘫痪。
