Saunders R D, Dugan L L, Demediuk P, Means E D, Horrocks L A, Anderson D K
J Neurochem. 1987 Jul;49(1):24-31. doi: 10.1111/j.1471-4159.1987.tb03388.x.
Traumatic injury of the spinal cord leads to a series of pathological events that result in tissue necrosis and paralysis. Among the earliest biochemical reactions are hydrolysis of fatty acids from membrane phospholipids, production of biologically active eicosanoids, and peroxidation of lipids. This study examines the effect of agents purported to improve recovery following spinal cord trauma, methylprednisolone sodium succinate (MPSS) and the combination of alpha-tocopherol and selenium (Se), on the posttraumatic alterations of membrane lipid metabolism. Pretreatment with either MPSS or alpha-tocopherol and Se reduced the trauma-induced release of total FFA including arachidonate in the injured spinal cord tissue. In addition, these agents decreased the postinjury levels of prostanoids. Pretreatment with either MPSS or alpha-tocopherol and Se also completely prevented the trauma-induced loss of cholesterol while inhibiting the increase of a cholesterol peroxidation product, 25-hydroxycholesterol. These data suggest that: perturbation of membrane lipid metabolism may contribute to the tissue necrosis and functional deficit of spinal cord injury and MPSS or the combination of alpha-tocopherol and Se may protect injured spinal cord tissue, at least in part, by limiting these posttraumatic membrane lipid changes.
脊髓创伤会引发一系列病理事件，导致组织坏死和瘫痪。最早出现的生化反应包括膜磷脂中脂肪酸的水解、生物活性类二十烷酸的产生以及脂质过氧化。本研究考察了据称能改善脊髓创伤后恢复的药物——甲泼尼龙琥珀酸钠（MPSS）以及α-生育酚与硒（Se）的组合——对创伤后膜脂质代谢变化的影响。用MPSS或α-生育酚与Se预处理可减少创伤诱导的损伤脊髓组织中包括花生四烯酸在内的总游离脂肪酸（FFA）释放。此外，这些药物降低了损伤后前列腺素的水平。用MPSS或α-生育酚与Se预处理还完全防止了创伤诱导的胆固醇损失，同时抑制了胆固醇过氧化产物25-羟基胆固醇的增加。这些数据表明：膜脂质代谢紊乱可能导致脊髓损伤的组织坏死和功能缺陷，而MPSS或α-生育酚与Se的组合可能至少部分地通过限制这些创伤后膜脂质变化来保护损伤的脊髓组织。
