Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain.
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain. Electronic address: https://twitter.com@F_Favaloro22.
Curr Opin Neurobiol. 2024 Dec;89:102926. doi: 10.1016/j.conb.2024.102926. Epub 2024 Oct 9.
The superior colliculus is a structure located in the dorsal midbrain with well conserved function and connectivity across species. Essential for survival, the superior colliculus has evolved to trigger rapid orientation and avoidance movements in response to external stimuli. The increasing recognition of the widespread connectivity of the superior colliculus, not only with brainstem and spinal cord, but also with virtually all brain structures, has rekindled the interest on this structure and revealed novel roles in the past few years. In this review, we focus on the most recent advancements in understanding its cellular composition, connectivity and function, with a particular focus on how the cellular diversity and connectivity arises during development, as well as on its recent role in the emergence of sensory circuits.
上丘是位于中脑背侧的一个结构，在不同物种中具有高度保守的功能和连接性。上丘对于生存至关重要，它已经进化为能够对外界刺激做出快速的定向和回避运动。近年来，人们对上丘广泛的连接性的认识不断加深，不仅与脑干和脊髓相连，而且与几乎所有的大脑结构都相连，这重新激发了人们对该结构的兴趣，并揭示了其新的作用。在这篇综述中，我们重点介绍了对上丘细胞组成、连接和功能的最新认识，特别关注细胞多样性和连接性是如何在发育过程中产生的，以及它在感觉回路出现中的最新作用。
