Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, Aachen 52074, Germany; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Nuclear Engineering and Department of Chemistry, University of California, Berkeley, CA, 94720, USA.
Toxicology. 2024 Dec;509:153967. doi: 10.1016/j.tox.2024.153967. Epub 2024 Oct 9.
As the use of lanthanides increases in many industries, concerns regarding their impact on human health rise. However, until recently, the toxicological profile of these elements had been incompletely characterized, with most studies relying on biodistribution assessments and lethal dose determinations in different animal models. In the last few years, the f-element field has started to pivot towards other examination types that identify cellular and molecular mechanisms of toxicity in a high-throughput manner. Under this new paradigm, functional genomics techniques, which rely on genetically modified cells or model organisms with missing genes or proteins, are becoming fundamental to gain novel insights into the genetic and proteomic bases of lanthanide toxicity, as well as to identify potential therapeutic targets to minimize the harmful effects of the metals. This review aims to provide an updated perspective on current efforts using functional genomics to characterize the toxicity and biological impact of lanthanides and improve their safety in different industrial applications.
随着镧系元素在许多行业中的应用增加，人们对它们对人类健康的影响的担忧也随之增加。然而，直到最近，这些元素的毒理学特征还没有完全被描述，大多数研究依赖于不同动物模型中的生物分布评估和致死剂量测定。在过去的几年中，镧系元素领域开始转向其他检查类型，这些检查类型以高通量的方式确定毒性的细胞和分子机制。在这个新的范例下，功能基因组学技术，依赖于具有缺失基因或蛋白质的基因修饰细胞或模式生物，对于深入了解镧系毒性的遗传和蛋白质组基础以及确定潜在的治疗靶点以最小化金属的有害影响变得至关重要。本文旨在提供一个关于当前使用功能基因组学来描述镧系元素的毒性和生物学影响并提高它们在不同工业应用中的安全性的最新观点。
