Constantin Marian, Chifiriuc Mariana Carmen, Vrancianu Corneliu Ovidiu, Petrescu Livia, Cristian Roxana-Elena, Crunteanu Ioana, Grigore Georgiana Alexandra, Chioncel Mariana F
Institute of Biology of Romanian Academy, 060031, Bucharest, Romania; The Research Institute of the University of Bucharest, ICUB, Bucharest, Romania.
The Research Institute of the University of Bucharest, ICUB, Bucharest, Romania; Microbiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095, Bucharest, Romania.
Environ Res. 2024 Dec 15;263(Pt 3):120235. doi: 10.1016/j.envres.2024.120235. Epub 2024 Oct 24.
Lanthanides, a group of elements with unique chemical properties, have garnered significant attention for their varied biological effects, ranging from cytotoxic to protective, depending on concentration, cell type, and exposure conditions. This review provides a detailed examination of the biological interactions of lanthanides with mammalian systems, including humans, by exploring their impact on different cell lines and organisms. Through a systematic assessment of current research, this work highlights the dual nature of lanthanides, identifying them as both potential therapeutic agents and environmental toxins. Furthermore, it underscores the importance of understanding their mechanisms to mitigate health risks, particularly for those exposed occupationally or via environmental sources. The review concludes with an overview of knowledge gaps and future research directions necessary for unlocking the therapeutic potential of lanthanides while ensuring safety and sustainability in their applications.
镧系元素是一组具有独特化学性质的元素，因其具有从细胞毒性到保护性的多种生物学效应而备受关注，这些效应取决于浓度、细胞类型和暴露条件。本综述通过探讨镧系元素对不同细胞系和生物体的影响，详细研究了它们与包括人类在内的哺乳动物系统的生物学相互作用。通过对当前研究的系统评估，这项工作突出了镧系元素的双重性质，将它们确定为潜在的治疗剂和环境毒素。此外，它强调了了解其作用机制以降低健康风险的重要性，特别是对于那些职业暴露或通过环境来源接触镧系元素的人。综述最后概述了知识空白以及未来的研究方向，这些对于释放镧系元素的治疗潜力同时确保其应用的安全性和可持续性是必要的。
