研讨会：微生物组能告诉我们什么来预防和治疗 AD/ADRD？
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
机构信息
University of California, Irvine, Irvine, California 92697.
National Institute of Neurological Disorders and Stroke, Rockville, Maryland 20852.
出版信息
J Neurosci. 2024 Oct 9;44(41):e1295242024. doi: 10.1523/JNEUROSCI.1295-24.2024.
Abstract
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.
摘要
阿尔茨海默病（AD）和与阿尔茨海默病相关的痴呆症（ADRDs）是广泛影响的多因素神经退行性疾病。它们的复杂性给开发有效的治疗方法带来了独特的挑战。这篇综述强调了在 2024 年神经科学学会会议上展示的研究，这些研究强调了肠道微生物组通过微生物群-肠-脑轴影响大脑功能和神经退行性变在 AD 发病机制中的作用。这一新兴证据突显了靶向肠道微生物组治疗 AD/ADRD 的潜力。
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