Li Tushuai, Sun Wenxue, Qian Da, Wang Peng, Liu Xingyu, He Chengsheng, Chang Tong, Liao Guangfu, Zhang Jie
School of Biology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, PR China.
Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China; Translational Pharmaceutical Laboratory, Jining No.1 People's Hospital, Shandong First Medical University, Jining 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining 272000, China.
Trends Biotechnol. 2025 Apr;43(4):802-811. doi: 10.1016/j.tibtech.2024.09.010. Epub 2024 Oct 8.
Hydrogels made of plant-derived biomass have gained popularity in biomedical applications because they are frequently affordable, readily available, and biocompatible. Finding the perfect plant-derived biomass-based hydrogels for biomedicine that can replicate essential characteristics of human tissues in regard to structure, function, and performance has proved to be difficult. In this review, we summarize some of the major contributions made to this topic, covering basic ideas and different biomass-based hydrogels made of cellulose, hemicellulose, and lignin. Also included is an in-depth discussion regarding the biosafety and toxicity assessments of biomass-based hydrogels. Finally, this review also highlights important scientific debates and major obstacles regarding biomass-based hydrogels for biomedical applications.
由植物源生物质制成的水凝胶在生物医学应用中越来越受欢迎，因为它们通常价格低廉、易于获取且具有生物相容性。事实证明，要找到一种完美的、基于植物源生物质的生物医学水凝胶，使其在结构、功能和性能方面能够复制人体组织的基本特征并非易事。在这篇综述中，我们总结了在该主题上的一些主要贡献，涵盖了基本概念以及由纤维素、半纤维素和木质素制成的不同的基于生物质的水凝胶。此外，还深入讨论了基于生物质的水凝胶的生物安全性和毒性评估。最后，本综述还强调了关于基于生物质的水凝胶在生物医学应用方面的重要科学争论和主要障碍。
