Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
NPJ Syst Biol Appl. 2024 Oct 9;10(1):117. doi: 10.1038/s41540-024-00446-1.
T cells are dynamically regulated immune cells that are implicated in a variety of diseases ranging from infection, cancer and autoimmunity. Recent advancements in sequencing methods have provided valuable insights in the transcriptional and epigenetic regulation of T cells in various disease settings. In this review, we identify the key sequencing-based methods that have been applied to understand the transcriptomic and epigenomic regulation of T cells in diseases.
T 细胞是具有动态调节功能的免疫细胞，与各种疾病（包括感染、癌症和自身免疫性疾病）有关。测序方法的最新进展为各种疾病背景下 T 细胞的转录和表观遗传调控提供了有价值的见解。在这篇综述中，我们确定了应用于了解疾病中 T 细胞转录组和表观基因组调控的关键基于测序的方法。
