Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan.
Department of Ophthalmology and Visual Science, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Sci Rep. 2024 Oct 9;14(1):23634. doi: 10.1038/s41598-024-73519-0.
To determine the characteristics of the changes in the amplitude of the flicker electroretinograms (ERGs) after combined cataract surgery and vitrectomy for an idiopathic epiretinal membrane (ERM). To accomplish this, we conducted a prospective study on 20 patients. Flicker ERGs and central macular thickness (CMT) were measured before the surgery (baseline), and at 1 week, 1 month, 3 months, and 6 months postoperatively. The mean amplitude of the flicker ERGs increased significantly by 63.5% at 1 week after surgery (P < 0.001) and then gradually decreased. The amplitude at 6 months was not significantly different from the baseline amplitude. This transient increase in the flicker ERG amplitudes after ERM surgery suggests that electrophysiologic evaluations of the therapeutic effects of vitrectomy should be performed 6 months postoperatively. The mean CMT decreased significantly at 1 week postoperatively (P < 0.001) and continued to decrease progressively over six months. The relative increase of amplitude at 1 week was significantly associated with the relative decrease of CMT at 6 months, and evaluation of retinal functional changes at 1 week may be able to predict the postoperative course of the ERM.
探讨特发性视网膜内界膜（ERM）合并白内障手术后闪烁视网膜电图（ERG）振幅变化的特点。方法：前瞻性研究 20 例患者。在手术前（基线）、术后 1 周、1 个月、3 个月和 6 个月测量闪烁 ERG 和中心黄斑厚度（CMT）。术后 1 周闪烁 ERG 振幅增加 63.5%（P<0.001），然后逐渐下降。术后 6 个月的振幅与基线振幅无显著差异。ERM 手术后闪烁 ERG 振幅的这种短暂增加表明，术后 6 个月应进行玻璃体切除术疗效的电生理评估。术后 1 周 CMT 显著降低（P<0.001），并在 6 个月内持续逐渐下降。术后 1 周振幅的相对增加与术后 6 个月 CMT 的相对降低显著相关，对 1 周时视网膜功能变化的评估可能能够预测 ERM 的术后病程。
