Erdinest Nir, London Naomi, Ovadia Haim, Levinger Nadav
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Private Pracitce, Jerusalem 94228, Israel.
Vision (Basel). 2021 Jun 9;5(2):29. doi: 10.3390/vision5020029.
Nitric oxide (NO) is acknowledged as a vital intercellular messenger in multiple systems in the body. Medicine has focused on its functions and therapeutic applications for decades, especially in cardiovascular and nervous systems, and its role in immunological responses. This review was composed to demonstrate the prevalence of NO in components of the ocular system, including corneal cells and multiple cells in the retina. It discussed NO's assistance during the immune, inflammation and wound-healing processes. NO is identified as a vascular endothelial relaxant that can alter the choroidal blood flow and prompt or suppress vascular changes in age-related macular degeneration and diabetes, as well as the blood supply to the optic nerve, possibly influencing the progression of glaucoma. It will provide a deeper understanding of the role of NO in ocular homeostasis, the delicate balance between overproduction or underproduction and the effect on the processes from aqueous outflow and subsequent intraocular pressure to axial elongation and the development of myopia. This review also recognized the research and investigation of therapies being developed to target the NO complex and treat various ocular diseases.
一氧化氮（NO）被公认为是人体多个系统中至关重要的细胞间信使。几十年来，医学一直专注于其功能和治疗应用，尤其是在心血管和神经系统以及其在免疫反应中的作用。本综述旨在阐述NO在眼系统各组成部分中的普遍存在情况，包括角膜细胞和视网膜中的多种细胞。它讨论了NO在免疫、炎症和伤口愈合过程中的辅助作用。NO被认为是一种血管内皮舒张剂，可改变脉络膜血流，并促使或抑制年龄相关性黄斑变性和糖尿病中的血管变化，以及对视神经的血液供应，可能影响青光眼的进展。这将更深入地理解NO在眼内稳态中的作用、过量产生或产生不足之间的微妙平衡以及对从房水流出及随后的眼压到眼轴伸长和近视发展等过程的影响。本综述还认可了针对NO复合物开发治疗方法并治疗各种眼部疾病的研究和调查。
