大型城市医疗中心员工中对 SARS-CoV-2 血清阳性的预测因素。
Predictors of seropositivity to SARS-CoV-2 among employees at a large urban medical center.
机构信息
Division of Infectious Diseases, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Lundquist Institute of Biomedical Innovation at Harbor-UCLA Medical Center, United States, 1124 W. Carson St, Torrance, CA, 90502, USA.
出版信息
BMC Public Health. 2024 Oct 9;24(1):2754. doi: 10.1186/s12889-024-20274-6.
BACKGROUND
Before SARS-CoV-2 vaccination availability, medical center employees were at high risk of COVID-19. However, risk factors for SARS-CoV-2 infection in medical center employees, both healthcare and non-healthcare workers, are poorly understood.
METHODS
From September-December 2020, free IgG antibody testing was offered to all employees at a large urban medical center. Participants were asked to complete a questionnaire on work and non-work related risk factors for COVID-19 infection.
RESULTS
SARS-CoV-2 seropositivity was found in 4.7%. Seropositivity was associated with close contact with COVID-19 cases with or without the use of adequate personal protective equipment (PPE), (OR 3.1 [95% CI 1.4-6.9] and OR 4.7 [95% CI 2.0-11.0] respectively), never wearing a mask outside of work (OR 10.1 [95% CI 1.9-57]), and Native Hawaiian/Pacific Islander race (OR 6.3 95% CI (1.6-25)].
CONCLUSIONS
Among workers in a large urban medical center, SARS-CoV-2 seropositivity was associated with work-related COVID-19 close contacts and low mask use outside of work, suggesting that non-workplace close contacts are also relevant routes of COVID-19 spread among healthcare workers.
背景
在 SARS-CoV-2 疫苗可获得之前，医疗中心的员工面临着 COVID-19 的高风险。然而，医疗中心员工（包括医护人员和非医护人员）感染 SARS-CoV-2 的风险因素尚未得到充分了解。
方法
2020 年 9 月至 12 月，为一家大型城市医疗中心的所有员工提供免费 IgG 抗体检测。参与者被要求填写一份关于工作和非工作相关 COVID-19 感染风险因素的问卷。
结果
发现 SARS-CoV-2 血清阳性率为 4.7%。血清阳性与与 COVID-19 病例密切接触有关，无论是否使用适当的个人防护设备（OR3.1 [95%CI1.4-6.9] 和 OR4.7 [95%CI2.0-11.0]），从不工作时戴口罩（OR10.1 [95%CI1.9-57]）以及原住民夏威夷/太平洋岛民种族（OR6.3 [95%CI1.6-25]）。
结论
在一家大型城市医疗中心的工作人员中，SARS-CoV-2 血清阳性与工作相关的 COVID-19 密切接触以及工作外低口罩使用率有关，这表明非工作场所的密切接触也是医护人员 COVID-19 传播的相关途径。
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