Danysz W, Kostowski W, Hauptmann M
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):855-64.
Desipramine (DMI) effectively antagonized hypothermia induced by reserpine and clonidine in rats. DMI effects were attenuated or even abolished after electrolytic or 6-hydroxydopamine-induced lesion of the locus coeruleus (LC) as well as by administration of DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), a selective noradrenergic neurotoxin. Contrary to the LC lesions, electrolytic destruction of the ventral noradrenergic bundle did not change DMI action but antagonized reserpine-induced hypothermia by itself. Our results underline a possible involvement of the LC system in mechanism of antidepressive action, which was suggested previously in this laboratory.
地昔帕明（DMI）可有效对抗利血平和可乐定诱导的大鼠体温过低。在用电解或6-羟基多巴胺诱导蓝斑（LC）损伤后，以及通过给予选择性去甲肾上腺素能神经毒素DSP-4（N-（2-氯乙基）-N-乙基-2-溴苄胺）后，DMI的作用减弱甚至消失。与LC损伤相反，腹侧去甲肾上腺素能束的电解破坏并没有改变DMI的作用，但自身可对抗利血平诱导的体温过低。我们的结果强调了LC系统可能参与抗抑郁作用机制，这在本实验室之前已有提示。
