Płaźnik A, Danysz W, Kostowski W
Pol J Pharmacol Pharm. 1985 May-Jun;37(3):347-57.
The role of mesolimbic monoaminergic innervation in the organization of rat behavior in the forced swim test (FST) and in the anti-immobilizing action of desipramine (DMI) in the test, was examined. The results can be summarized as follows: neither 6-hydroxydopamine (60HDA)-lesions nor electrical stimulation of the ventral tegmental area (A-10) and intra-accumbens dopamine (DA) microinjections produced specific (i.e. independent from changes in rats locomotion) effects on rat behavior or on DMI action in the FST. On the other hand, 60HDA lesions to the locus coeruleus (LC) antagonized the anti-immobilizing effect of DMI. It was also shown by us that the electrostimulation of the LC produced in the FST an effect similar to that of DMI. Moreover, the intra-accumbens injections of noradrenaline (NA) mimicked the effect of DMI in the test. Similar results were obtained after local administration of adrenergic receptor agonists--phenylephrine and isoproterenol. It is concluded that NA but not DA plays a crucial role in the organization of rat behavior in the FST and in the anti-immobilizing effect of DMI. The data suggest also a direct involvement of the nucleus accumbens septi in these neural processes.
研究了中脑边缘单胺能神经支配在强迫游泳试验（FST）中大鼠行为组织以及地昔帕明（DMI）在该试验中的抗固定作用中的作用。结果总结如下：6-羟基多巴胺（6-OHDA）损伤、腹侧被盖区（A-10）的电刺激以及伏隔核内多巴胺（DA）的微量注射均未对FST中大鼠的行为或DMI的作用产生特异性（即独立于大鼠运动变化）影响。另一方面，蓝斑（LC）的6-OHDA损伤拮抗了DMI的抗固定作用。我们还表明，FST中LC的电刺激产生了与DMI相似的效果。此外，伏隔核内注射去甲肾上腺素（NA）模拟了试验中DMI的效果。局部给予肾上腺素能受体激动剂苯肾上腺素和异丙肾上腺素后也获得了类似结果。得出的结论是，NA而非DA在FST中大鼠行为组织以及DMI的抗固定作用中起关键作用。数据还表明伏隔核在这些神经过程中直接参与。
