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transcriptomic analysis of spermatocytes in non-obstructive azoospermia reveals senescence-like states in arrested spermatocytes.

作者信息

Wu Zhongqin, Wu Xiaolong, Xu Zeqian, Liu Yixin, Zhu Ziyi, Li Xinhui, Czajkowsky Daniel M, Sun Fei, Guo Yan, Shao Zhifeng

机构信息

State Key Laboratory of Systems Medicine for Cancer, School of Biomedical Engineering and Bio-ID Center, Shanghai Jiao Tong University, Shanghai 200240, China.

Department of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

出版信息

Genes Dis. 2024 Jan 3;12(1):101205. doi: 10.1016/j.gendis.2024.101205. eCollection 2025 Jan.

DOI:10.1016/j.gendis.2024.101205
PMID:39386102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11462241/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/3bc163689128/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/49c6972db1c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/d6d69e8b0ae6/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/3bc163689128/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/49c6972db1c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/d6d69e8b0ae6/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/11462241/3bc163689128/figs2.jpg

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本文引用的文献

1
Improved phenotypic classification of male infertility to promote discovery of genetic causes.提高男性不育症的表型分类，以促进遗传原因的发现。
Nat Rev Urol. 2024 Feb;21(2):91-101. doi: 10.1038/s41585-023-00816-0. Epub 2023 Sep 18.
2
E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling.E2F1 通过影响 WNT4 信号调节睾丸下降并控制精子发生。
Development. 2021 Jan 13;148(1):dev191189. doi: 10.1242/dev.191189.
3
Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ.
使用激光捕获显微切割和 Smart-3SEQ 对存档组织中的单细胞进行基因表达谱分析。
Genome Res. 2019 Nov;29(11):1816-1825. doi: 10.1101/gr.234807.118. Epub 2019 Sep 13.
4
The role of senescent cells in ageing.衰老细胞在衰老过程中的作用。
Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193.
5
BNC1 is required for maintaining mouse spermatogenesis.维持小鼠精子发生需要BNC1。
Genesis. 2012 Jul;50(7):517-24. doi: 10.1002/dvg.22014. Epub 2012 Feb 20.