Jang Ye Lim, Park Min Kyu
Department of Clinical Pharmacology and Therapeutics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju 28644, Korea.
Transl Clin Pharmacol. 2024 Sep;32(3):137-149. doi: 10.12793/tcp.2024.32.e11. Epub 2024 Sep 23.
A hangover is a combination of negative mental and physical symptoms, such as headache, diarrhea, and loss of appetite, that occur after alcohol consumption and can vary depending on individual genetic and environmental factors. To quickly relieve these hangover symptoms, a new hangover relief compound called HK-GCM-H01 has been developed. This compound, HK-GCM-H01, consists of fermented rice germ extracts, yeast extract mixtures, cili extract powder, and concentrated nipafam powder, all of which are known to relieve hangover symptoms. The safety and clinical symptoms of HK-GCM-H01 were evaluated, along with the pharmacokinetic properties of alcohol and acetaldehyde after its administration. This study was conducted on 50 healthy Korean men using a randomized, double-blind, placebo-controlled, single-intake, crossover design. To evaluate clinical symptoms, Acute Hangover Scale and Alcohol Hangover Severity Scale were used, and the pharmacokinetic evaluation parameters included the maximum plasma concentration, the time to peak plasma concentration, the terminal half-life, and the area under the plasma concentration-time curve from X hours to Y hours. A significant reduction in clinical symptoms was observed after alcohol consumption in the group that consumed HK-GCM-H01 with added hangover relief compound, as was a significant decrease in blood exposure to acetaldehyde compared to the placebo group. There were no adverse events or significant changes in liver function indicators reported during the safety evaluation. These findings indicate that HK-GCM-H01 is safe and significantly reduces plasma concentrations of acetaldehyde, the main cause of hangover, suggesting that it improves hangover symptoms.
宿醉是饮酒后出现的一系列负面身心症状，如头痛、腹泻和食欲不振，其症状会因个体遗传和环境因素而有所不同。为了快速缓解这些宿醉症状，一种名为HK - GCM - H01的新型宿醉缓解化合物已被研发出来。这种化合物HK - GCM - H01由发酵米胚芽提取物、酵母提取物混合物、刺梨提取物粉末和浓缩尼泊酯粉末组成，所有这些成分都已知具有缓解宿醉症状的作用。对HK - GCM - H01的安全性、临床症状以及给药后酒精和乙醛的药代动力学特性进行了评估。本研究采用随机、双盲、安慰剂对照、单次摄入、交叉设计，对50名健康韩国男性进行了研究。为了评估临床症状，使用了急性宿醉量表和酒精性宿醉严重程度量表，药代动力学评估参数包括最大血浆浓度、血浆浓度达峰时间、末端半衰期以及从X小时到Y小时的血浆浓度 - 时间曲线下面积。在摄入添加了宿醉缓解化合物的HK - GCM - H01的组中，饮酒后观察到临床症状显著减轻，与安慰剂组相比，血液中乙醛暴露量也显著降低。在安全性评估期间，未报告不良事件或肝功能指标的显著变化。这些发现表明，HK - GCM - H01是安全的，并且能显著降低宿醉的主要原因——乙醛的血浆浓度，这表明它能改善宿醉症状。
