Watanabe Yuri, Shibata Takashi, Tanaka Mieko, Ishii Kenji, Higuchi Yuko, Kobayashi Yohei, Kosugi Yukio
Brain Functions Laboratory, Inc., Tokyo, Japan.
Department of Neurosurgery, Toyama University Hospital, Toyama, Japan.
Front Hum Neurosci. 2024 Sep 25;18:1438924. doi: 10.3389/fnhum.2024.1438924. eCollection 2024.
The alpha rhythm in human electroencephalography (EEG) is known to decrease in frequency with age. Previous study has shown that elderly individuals with dementia exhibit higher S values (spatial variability) and SD values (temporal variability) in the triple correlation of the occipital region (P3, P4, Oz) compared to healthy elderly individuals. The objective of this research is to examine changes in S and SD values of the alpha band with aging in healthy individuals using triple correlation values from the frontal region. The subjects were 50 healthy elderly subjects (mean age 73.0 ± 5.1 years), 34 healthy younger subjects (mean age 28.1 ± 4.6 years), and 21 dementia patients (mean age 70.1 ± 9.1 years). The methodology involved recording EEG for 5 min during rest with closed eyes, and then calculating S and SD values of the alpha band (8-13 Hz) using three electrodes in the frontal region (F3, F4, Fpz). The findings indicated that the S values of young individuals were significantly higher than those of elderly individuals ( < 0.01), whereas the SD values of young individuals tended to be lower than those of elderly individuals. The elevated S values in young individuals imply greater spatial variability akin to individuals with dementia, whereas the reduced SD values in young individuals suggest lower temporal variability unlike individuals with dementia. The discrepancy between the S value and SD value in healthy young individuals suggests that the normal cortical dipole in the frontal regions might be more abundant in them compared to healthy elderly individuals.
人类脑电图（EEG）中的α波节律已知会随着年龄增长而频率降低。先前的研究表明，与健康老年人相比，患有痴呆症的老年人在枕叶区域（P3、P4、Oz）的三重相关性中表现出更高的S值（空间变异性）和SD值（时间变异性）。本研究的目的是使用额叶区域的三重相关性值来检查健康个体中α波段的S值和SD值随年龄的变化。受试者包括50名健康老年受试者（平均年龄73.0±5.1岁）、34名健康年轻受试者（平均年龄28.1±4.6岁）和21名痴呆症患者（平均年龄70.1±9.1岁）。该方法包括在闭眼休息期间记录5分钟的脑电图，然后使用额叶区域的三个电极（F3、F4、Fpz）计算α波段（8 - 13Hz）的S值和SD值。研究结果表明，年轻个体的S值显著高于老年个体（<0.01），而年轻个体的SD值往往低于老年个体。年轻个体中升高的S值意味着与痴呆症患者相似的更大空间变异性，而年轻个体中降低的SD值表明与痴呆症患者不同的较低时间变异性。健康年轻个体中S值和SD值之间的差异表明，与健康老年个体相比，他们额叶区域的正常皮质偶极可能更为丰富。
