Chyrek-Borowska S, Kuczewska B, Hofman J, Szymański W, Lukaszewicz D
Arch Immunol Ther Exp (Warsz). 1985;33(6):777-82.
Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunotherapy a significant drop in anti-IgE and specific antigen-induced histamine release from isolated basophils occurs. The investigations confirm that the diminution of the target cell sensitivity and releasability may be one of the effects of specific immunotherapy.
评估了抗IgE和抗原诱导的从30名对草花粉过敏原敏感的特应性患者分离出的嗜碱性粒细胞中组胺的释放情况。研究在使用戊二醛-花粉-酪氨酸吸附物（Pollinex）进行短期免疫治疗前后进行。结果显示，免疫治疗后，从分离出的嗜碱性粒细胞中抗IgE和特异性抗原诱导的组胺释放显著下降。这些研究证实，靶细胞敏感性和释放能力的降低可能是特异性免疫治疗的效果之一。
