Department of Cardiac Rehabilitation, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Front Public Health. 2024 Sep 25;12:1407146. doi: 10.3389/fpubh.2024.1407146. eCollection 2024.
The goal of this study is to assess the clinical attributes exhibited by patients aged 85 years and older who present different manifestations of COVID-19, and to examine the factors influencing the classification of the disease severity.
This retrospective study was conducted at a single center, encompassing an analysis of clinical data obtained from patients with COVID-19 admitted to a general geriatric hospital in Hangzhou, Zhejiang, China, during the period from December 20, 2022, to February 1, 2023. The study focused on 91 eligible patients whose disease severity was compared based on the imaging findings.
A total of 91 patients aged 85 years and older, with a median age of 92, including 46 males, 10 exhibiting mild symptoms, 48 moderate cases, and 33 severe cases met the inclusion criteria. Notably, disease severity displayed a significant correlation with age ( < 0.011). All patients presented with complicated chronic underlying conditions and a history of prolonged medication use. Rheumatic immune diseases ( = 0.040) and endocrine medications, primarily hypoglycemic agents ( = 0.034), exhibited statistical significance. Additionally, markers such as lactate dehydrogenase (LDH) ( = 0.030), interleukin 6 (IL-6) ( = 0.014), and D-dimer ( = 0.007) revealed significant associations with disease severity. Chest computed tomography scans predominantly revealed inflammatory features ( = 81, 89.0%). Notably, patients classified as having mild or moderate conditions exhibited eventual improvement, while 13 patients (39.4%) among the severe cases succumbed to the disease.
The classification of disease among patients aged 85 years or older old is correlated with advanced age, concurrent rheumatic immune diseases, and prolonged administration of endocrine medications. Furthermore, patients with elevated levels of LDH, IL-6, and D-dimer demonstrated a higher propensity for developing severe diseases.
本研究旨在评估 85 岁及以上表现出不同 COVID-19 症状的患者的临床特征，并探讨影响疾病严重程度分类的因素。
这是一项单中心回顾性研究，分析了 2022 年 12 月 20 日至 2023 年 2 月 1 日期间入住中国浙江杭州一家综合老年医院的 COVID-19 患者的临床数据。该研究重点关注了 91 名符合条件的患者，根据影像学表现比较了他们的疾病严重程度。
共纳入 91 名 85 岁及以上的患者，中位年龄为 92 岁，其中男性 46 例，轻症 10 例，中度 48 例，重症 33 例。值得注意的是，疾病严重程度与年龄显著相关（<0.011）。所有患者均患有复杂的慢性基础疾病，并长期服用药物。风湿免疫性疾病（=0.040）和内分泌药物，主要是降糖药（=0.034）具有统计学意义。此外，乳酸脱氢酶（LDH）（=0.030）、白细胞介素 6（IL-6）（=0.014）和 D-二聚体（=0.007）等标志物与疾病严重程度也存在显著关联。胸部计算机断层扫描（CT）主要显示炎症特征（=81，89.0%）。值得注意的是，轻度或中度患者最终病情有所改善，而 13 名（39.4%）重症患者死亡。
85 岁及以上患者的疾病分类与高龄、并发风湿免疫性疾病和长期使用内分泌药物有关。此外，LDH、IL-6 和 D-二聚体水平升高的患者更有可能发展为严重疾病。
