Ribeiro Victor P, Bastos Jairo K, Harries Marcuslene D, Page Phaedra N, Techen Natascha, Meepagala Kumudini M
Agricultural Research Service, United States Department of Agriculture, Natural Products Utilization Research Unit, University, Mississippi, USA.
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
J Fish Dis. 2024 Oct 10:e14030. doi: 10.1111/jfd.14030.
Edwardsiella ictaluri and Flavobacterium covae are two bacteria species that cause diseases in farm-raised channel catfish (Ictalurus punctatus) that cause heavy economic damage to the aquaculture industry, particularly to the channel catfish farming. In search for environmentally benign antibacterial compounds active against E. ictaluri and F. covae, we investigated the constituents isolated from Brazilian red, brown and green propolis. We have also synthetically modified active constituents to see if lipophilicity plays a role in enhancing antibacterial activities. Vestitol, neovestitol and methylvestitol were found to be the active constituents with minimum inhibitory concentration (MIC) relative to drug control florfenicol (RDCF) values (MICRDCF) of 7.6, 7.6 and 7.9 mg/L, respectively, against F. covae. The activity against E. ictaluri was not significant.
鮰爱德华氏菌和科瓦黄杆菌是两种可在养殖的沟鲶（斑点叉尾鮰）中引发疾病的细菌，这给水产养殖业，尤其是沟鲶养殖造成了严重的经济损失。为寻找对鮰爱德华氏菌和科瓦黄杆菌具有活性的环境友好型抗菌化合物，我们研究了从巴西红蜂胶、棕蜂胶和绿蜂胶中分离出的成分。我们还对活性成分进行了合成修饰，以探究亲脂性是否在增强抗菌活性方面发挥作用。结果发现，相对于药物对照氟苯尼考（RDCF），vestitol、新vestitol和甲基vestitol对科瓦黄杆菌的最小抑菌浓度（MIC）分别为7.6、7.6和7.9 mg/L，是活性成分。它们对鮰爱德华氏菌的活性不显著。
