Jaros Scott C, Morrell Dean S, Nieman Elizabeth L
Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Dermatology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Pediatr Dermatol. 2025 Mar-Apr;42(2):364-370. doi: 10.1111/pde.15777. Epub 2024 Oct 10.
Eruptive melanocytic nevi (EMN) have been reported in the setting of immunosuppression, chemotherapy, and bullous skin disease, including less commonly, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This case report presents a 4-year-old girl who developed agminated EMN and nail changes after TEN. A systematic review of the literature supports clinically appropriate follow-up of EMN, as there is no reports of malignancy in EMN following SJS/TEN, nor reports of pediatric melanoma arising within EMN of any etiology. Further study of the possible correlation of nail changes with the development of EMN and better characterization of the dermoscopic features of EMN could improve monitoring and care of these patients.
已有报道称，在免疫抑制、化疗及大疱性皮肤病（包括较少见的史蒂文斯 - 约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN））的情况下会出现发疹性黑素细胞痣（EMN）。本病例报告介绍了一名4岁女孩，她在患TEN后出现了群集性EMN和指甲改变。对文献的系统回顾支持对EMN进行临床适当的随访，因为尚无SJS/TEN后EMN发生恶变的报道，也没有任何病因的EMN内发生儿童黑色素瘤的报道。进一步研究指甲改变与EMN发生的可能相关性以及更好地描述EMN的皮肤镜特征，可能会改善对这些患者的监测和护理。
