Gelfer Allison, Rivers Jason K
Pacific DermaAesthetics, 1790-1111 W Georgia St, Vancouver, BC V6E 4M3, Canada.
Arch Dermatol. 2007 Dec;143(12):1555-7. doi: 10.1001/archderm.143.12.1555.
Eruptive melanocytic nevi (MN) are a rare phenomenon characterized by the simultaneous, abrupt onset of hundreds of MN, often in a grouped distribution. There are few studies on this topic in the literature. We followed up a patient who developed eruptive MN 38 years ago after Stevens-Johnson syndrome. Herein we document this patient's progress and review the literature on this unusual phenomenon.
For 38 years, the patient's lesions have remained stable, without signs of malignant degeneration. We discuss the possible etiology and natural history of this condition in 2 major patient populations: those with bullous disorders and those with systemic immunosuppression.
We postulate that the etiology and natural course of eruptive MN may differ between the 2 main populations of patients at risk for eruptive MN, with MN arising after bullous disorders being more likely to remain benign compared with those in patients with ongoing immunosuppression. However, this hypothesis has yet to be proved, and it will require long-term surveillance of individuals who have developed eruptive MN to determine its merit.
发疹性黑素细胞痣（MN）是一种罕见现象，其特征为数百个MN同时突然出现，常呈簇状分布。文献中关于该主题的研究较少。我们对一名38年前在史蒂文斯-约翰逊综合征后发生发疹性MN的患者进行了随访。在此，我们记录该患者的病情进展并回顾关于这一不寻常现象的文献。
38年来，患者的皮损一直保持稳定，无恶性变迹象。我们在两类主要患者群体中讨论了这种情况的可能病因和自然病程：患有大疱性疾病的患者和有全身免疫抑制的患者。
我们推测，发疹性MN的病因和自然病程在两类主要的发疹性MN风险患者群体中可能有所不同，与持续免疫抑制患者相比，大疱性疾病后出现的MN更有可能保持良性。然而，这一假设尚未得到证实，需要对发生发疹性MN的个体进行长期监测以确定其价值。
