Merlocco Anthony, Hurst Daniel J
Department of Pediatrics, Division of Cardiology, University of Tennessee Health Science Center, Memphis, TN, USA.
LeBonheur Children's Hospital, 49 N. Dunlap St, 3rd Floor FOB, Memphis, TN, 38103, USA.
J Bioeth Inq. 2024 Oct 10. doi: 10.1007/s11673-024-10377-5.
The transplantation of non-human organs into humans, or xenotransplantation (XTx), has recently garnered new attention and is being developed to help address the problem of organ scarcity in transplantation. Ethical issues surrounding XTx have been studied since initial interest arose decades ago and have experienced renewed discussion in the literature. However, the distinct and relevant differences when applied to children has largely been overlooked with few groups attending to the concerns that XTx in children raises. In this paper, we explore ethical challenges to be expected in paediatric XTx, in particular exploring organ sizing concerns, infectious risks, psychological burdens, and issues of moral hazard. We review these domains with the aim of highlighting the implications of pursuing paediatric XTx and the cross-disciplinary approach needed to solve these issues. Children require a unique analysis from a bioethical perspective to best prepare for the issues XTx presents.
将非人类器官移植到人类体内，即异种移植，最近重新受到关注，并且正在发展以帮助解决移植中器官短缺的问题。自从几十年前首次引起关注以来，围绕异种移植的伦理问题就一直在研究，并且在文献中经历了重新讨论。然而，当应用于儿童时，明显且相关的差异在很大程度上被忽视了，很少有团体关注儿童异种移植所引发的问题。在本文中，我们探讨了儿科异种移植中可能出现的伦理挑战，特别是探讨器官大小问题、感染风险、心理负担和道德风险问题。我们审视这些领域，旨在突出追求儿科异种移植的影响以及解决这些问题所需的跨学科方法。从生物伦理角度来看，儿童需要进行独特的分析，以便为异种移植带来的问题做好最佳准备。
