Kakutani T, Yamaoka K, Hashida M, Sezaki H
J Pharmacokinet Biopharm. 1985 Dec;13(6):609-31. doi: 10.1007/BF01058904.
A new experimental system is used to determine exact information concerning local drug disposition. Rabbit hind leg is perfused in situ using a single-pass technique, and outflow curves of drugs are analyzed using statistical moment theory. By the introduction of chromatographic concepts and the application of the well-stirred model to the local perfusion system, physiologically and/or physicochemically meaningful parameters are derived from the first three moments. Moreover, in the assessment, drug disposition is divided into elimination and distribution. The elimination process is also evaluated with respect to rate and extent. This system is used to elucidate the disposition characteristics of mitomycin C and its lipophilic derivative nonyloxycarbonyl mitomycin C.
一种新的实验系统用于确定有关局部药物处置的确切信息。使用单通道技术对兔后肢进行原位灌注，并使用统计矩理论分析药物的流出曲线。通过引入色谱概念并将充分搅拌模型应用于局部灌注系统，从前三个矩中得出生理和/或物理化学上有意义的参数。此外，在评估中，药物处置分为消除和分布。还从速率和程度方面评估消除过程。该系统用于阐明丝裂霉素C及其亲脂性衍生物壬氧羰基丝裂霉素C的处置特征。
