Chan K K
Drug Metab Dispos. 1982 Sep-Oct;10(5):474-9.
A simple integrated method for the calculation of elimination rate constants of a drug and its derived metabolite has been developed. This method is based on the statistical moment theory and requires only simple calculations of the area under the curve and area under the moment curve of the parent drug and its derived metabolite. The application to a drug following a one-compartmental model is theoretically well justified and this method may also be applicable to drugs following higher kinetic models under certain conditions. The application of this method to several experimental cases is also presented.
已开发出一种用于计算药物及其衍生代谢物消除速率常数的简单综合方法。该方法基于统计矩理论，仅需对母体药物及其衍生代谢物的曲线下面积和矩曲线下面积进行简单计算。该方法应用于单室模型药物在理论上有充分依据，并且在某些条件下也可能适用于具有更高动力学模型的药物。还介绍了该方法在几个实验案例中的应用。
