Yu Jia, Sun Hongyan, Zhu Jinhua, Wei Xintong, Shi Hongfei, Shen Bin, Ren Liyun, He Yan, Zhang Rongyan, Zhang Mingzhi, Peng Hao
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, People's Republic of China.
Center for Disease Prevention and Control of Tianning District, Changzhou, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Mar 25;14:1367-1374. doi: 10.2147/DMSO.S301363. eCollection 2021.
The relationship between obesity and hyperuricemia has been demonstrated by many studies. However, whether or to what extent metabolic condition influents the association between obesity and hyperuricemia was not clear. Here, we aimed to examine the association between obese-metabolic phenotype and hyperuricemia in a large sample of Chinese adults.
According to BMI and metabolic syndrome, obese-metabolic phenotype was defined as metabolically unhealthy obesity (MUO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO) and metabolically healthy non-obesity (MHNO)in the Tianning cohort (N=5072). We conducted a cross-sectional analysis between obese-metabolic phenotype and hyperuricemia, followed by a Mendelian Randomization analysis using GWAS summary data to confirm the causality between uric acid and BMI.
The average level of serum UA showed 41.87-higher μmol/L in participants with MHO (β=41.87, <0.001) and 63.18-higher μmol/L in participants with MUO (β=63.18, <0.001), compared to those with MHNO. Compared to participants with MHNO, those with MUO had the highest likelihood to have hyperuricemia (OR=4.56, <0.001), followed by those with MHO (OR=3.32, <0.001). Mendelian randomization analysis indicated that uric acid was more likely to be a consequence of BMI (β=0.059, =6.54×10).
MUO, in comparison with MHO, was significantly associated with hyperuricemia in Chinese adults.
许多研究已证实肥胖与高尿酸血症之间的关系。然而，代谢状况是否以及在何种程度上影响肥胖与高尿酸血症之间的关联尚不清楚。在此，我们旨在在中国成年人的大样本中研究肥胖代谢表型与高尿酸血症之间的关联。
根据BMI和代谢综合征，在天宁队列（N = 5072）中将肥胖代谢表型定义为代谢不健康肥胖（MUO）、代谢健康肥胖（MHO）、代谢不健康非肥胖（MUNO）和代谢健康非肥胖（MHNO）。我们对肥胖代谢表型与高尿酸血症进行了横断面分析，随后使用GWAS汇总数据进行孟德尔随机化分析，以确认尿酸与BMI之间的因果关系。
与MHNO参与者相比，MHO参与者的血清UA平均水平高41.87 μmol/L（β = 41.87，<0.001），MUO参与者的血清UA平均水平高63.18 μmol/L（β = 63.18，<0.001）。与MHNO参与者相比，MUO参与者患高尿酸血症的可能性最高（OR = 4.56，<0.001），其次是MHO参与者（OR = 3.32，<0.001）。孟德尔随机化分析表明，尿酸更可能是BMI的结果（β = 0.059，= 6.54×10）。
在中国成年人中，与MHO相比，MUO与高尿酸血症显著相关。
