Jørgensen Rasmus Møller, Bøttger Bjarke, Vestergaard Esben Thyssen, Kremke Britta, Bahnsen Rikke Frederiksen, Nielsen Bent Windelborg, Bruun Jens Meldgaard
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Regionshospitalet Randers, Randers, Denmark.
Front Pediatr. 2022 Jan 4;9:814166. doi: 10.3389/fped.2021.814166. eCollection 2021.
Childhood obesity is an increasing condition associated with continuous obesity into adulthood and development of comorbidities. Adult studies show an association between serum uric acid (SUA) levels and body mass index (BMI). The aim of this retro perspective exploratory study was to investigate SUA in obese children and adolescents and the effects of a subsequent weight reduction. One hundred and seventy-one children (age 4-18), with obesity (i.e. BMI-SDS of +2 or higher) were included in a multifactorial lifestyle intervention. The children participating were annually measured for anthropometrics, blood samples and DEXA-scans for up to 3 years. Eighty-nine children were included for follow-up analysis. After a follow-up of 20.7 ± 9.4 months a reduction in BMI-SDS of -0.34 ± 0.53 ( < 0.01) was observed. SUA was found to be positively associated with changes in BMI-SDS. SUA levels decreased in the 65 children who lost weight during the trial, conversely, SUA increased in the 23 children who gained weight during the trial ( < 0.01 between groups). SUA was found to correlate with measures of obesity and for the first time, this intervention demonstrates a positive relationship between SUA and weight reduction in children with obesity.
儿童肥胖症是一种日益普遍的病症，与成年期持续肥胖及并发疾病的发展相关。成人研究表明血清尿酸（SUA）水平与体重指数（BMI）之间存在关联。这项回顾性探索性研究的目的是调查肥胖儿童和青少年的SUA情况以及随后体重减轻的影响。171名年龄在4至18岁的肥胖儿童（即BMI-SDS为+2或更高）被纳入多因素生活方式干预。参与的儿童每年进行人体测量、采集血样并进行DEXA扫描，为期长达3年。89名儿童被纳入随访分析。经过20.7±9.4个月的随访，观察到BMI-SDS降低了-0.34±0.53（<0.01）。发现SUA与BMI-SDS的变化呈正相关。在试验期间体重减轻的65名儿童中SUA水平下降，相反，在试验期间体重增加的23名儿童中SUA升高（组间<0.01）。发现SUA与肥胖指标相关，并且首次通过这项干预证明了肥胖儿童中SUA与体重减轻之间存在正相关关系。
