Public Health Department, Jilin University, Changchun, China.
Occupational Health Department, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.
PLoS One. 2024 Oct 10;19(10):e0311736. doi: 10.1371/journal.pone.0311736. eCollection 2024.
This study aimed to examine the association between inflammation-related indicators (IRIs) and telomere length (TL) in Chinese sanitation workers.
This study adopted a case-control design, conducted from January to December 2022 in Shenzhen, a city in eastern China. A total of 80 sanitation workers, as well as 80 matched controls, were randomly recruited from the Luohu district of Shenzhen city in China. Their blood samples were collected and analyzed for the IRIs and TL in the Medical Laboratory of Shenzhen Prevention and Treatment Center for Occupational Diseases. The relationship between IRIs and TL was analyzed using multivariate linear regression, and their dose-response relationship was explored using restricted cubic spline analysis.
The systemic inflammatory index (SII), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were significantly elevated in the sanitation workers in comparison to the controls. Moreover, the lymphocyte count (LYM), serum albumin concentration (ALB), and TL were found to be lower in the sanitation workers compared to the controls (P < 0.05). After adjusting for potential confounding variables, LYM was negatively correlated with TL in the sanitation workers (β = -0.31, 95% CI: -0.57, -0.05), whereas no correlation was observed in the controls. Furthermore, ALB demonstrated a non-linear relationship with TL in sanitation workers.
We found higher novel inflammatory markers (SII, PLR, and NLR) in the sanitation workers, and identified a correlation between LYM and ALB with shortened TL in them, providing new evidence for the effect of elevated inflammation on accelerated aging in Chinese sanitation workers.
本研究旨在探讨中国环卫工人炎症相关指标（IRIs）与端粒长度（TL）之间的关系。
本研究采用病例对照设计，于 2022 年 1 月至 12 月在中国东部城市深圳进行。共从深圳市罗湖区随机招募 80 名环卫工人和 80 名匹配对照。采集他们的血样，在中国深圳市职业病防治院医学检验科分析 IRIs 和 TL。采用多元线性回归分析 IRIs 与 TL 之间的关系，采用限制性立方样条分析探讨其剂量反应关系。
与对照组相比，环卫工人的全身炎症指数（SII）、血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）显著升高。此外，与对照组相比，环卫工人的淋巴细胞计数（LYM）、血清白蛋白浓度（ALB）和 TL 较低（P<0.05）。在调整潜在混杂因素后，LYM 与环卫工人的 TL 呈负相关（β=-0.31，95%CI：-0.57，-0.05），而对照组则无相关性。此外，ALB 与环卫工人的 TL 呈非线性关系。
我们发现环卫工人的新型炎症标志物（SII、PLR 和 NLR）水平较高，并且在环卫工人中发现 LYM 和 ALB 与 TL 缩短有关，为炎症升高对中国环卫工人加速衰老的影响提供了新的证据。
