Department of Molecular Microbiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA.
Department of Molecular Microbiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA.
Cell Host Microbe. 2024 Oct 9;32(10):1639-1641. doi: 10.1016/j.chom.2024.09.006.
Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.
抗噬菌体防御系统必须快速感知和应对各种病毒。最近在《自然》杂志上发表的两篇论文通过结构和功能分析揭示了 PARIS 防御系统（一种新发现的毒素-抗毒素系统）如何感知噬菌体相关分子模式（PhAMPs），从而激活内切核酸酶毒素，切割 tRNA 以阻止噬菌体复制。
