Department of Energy, Environmental, and Chemical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA.
Clarity Bio Systems India Pvt. Ltd., Pune, India.
Biotechnol Adv. 2024 Dec;77:108464. doi: 10.1016/j.biotechadv.2024.108464. Epub 2024 Oct 9.
Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.
生物技术建立在少数特征明确、工程设计良好的生物体的基础上。近年来，一种新的生物工程工具——海盐水生菌（Vibrio natriegens）引起了人们的关注。本综述介绍了利用大型语言模型（LLM）和知识图谱加速文献调查过程，将海盐水生菌作为生物技术平台的最新研究进展。科学家们在海盐水生菌的基础代谢特征、合成生物学工具的开发和表征、系统生物学分析和代谢建模、生物生产和代谢工程以及微生物生态学等方面都取得了研究进展。这些子类别都与海盐水生菌在生物工程应用中的未来相关。在本综述中，我们介绍了这些最新进展，并为它们可能对该领域产生的影响提供了背景信息，强调了使用该生物体的优缺点。从最近的生物工程研究来看，海盐水生菌似乎即将成为未来生物技术的平台细菌。
