麻风病中的α-1抗胰蛋白酶

Alpha-1-antitrypsin in leprosy.

作者信息

Deshpande S V, Zawar P B, Chawhan R N, Sengupta S R, Mehta M C

出版信息

Indian J Lepr. 1985 Oct-Dec;57(4):767-72.

Abstract

Estimation of Alpha-1-antitrypsin (AAT) levels was carried out in 52 patients of various types of leprosy. Fifty age and sex matched healthy individuals served as controls. The mean level of AAT in controls was 290.12 +/- 59.56 mg/dl. In patients of tuberculoid leprosy (TT), borderline tuberculoid leprosy (BT) and borderline leprosy (BB), the AAT levels were found to be 284 +/- 47.03, 314.37 +/- 31.56 and 324.44 +/- 32.05 mg/dl respectively. These were statistically insignificantly raised when compared with controls. In borderline lepromatous leprosy (BL), lepromatous leprosy without erythema nodosum leprosum (LL without ENL) and in LL with ENL there was a statistically significant rise in AAT levels. The maximum levels of AAT were observed in patients of LL with ENL (mean 500.8 +/- 93.44 mg/dl. P less than 0.001).

摘要

对52例不同类型麻风病患者进行了α-1抗胰蛋白酶（AAT）水平测定。选取50名年龄和性别匹配的健康个体作为对照。对照组AAT的平均水平为290.12±59.56mg/dl。在结核样型麻风（TT）、界线类偏结核样型麻风（BT）和界线类麻风（BB）患者中，AAT水平分别为284±47.03、314.37±31.56和324.44±32.05mg/dl。与对照组相比，这些水平虽有升高，但无统计学意义。在界线类偏瘤型麻风（BL）、无结节性红斑的瘤型麻风（LL无ENL）和有结节性红斑的LL患者中，AAT水平有统计学意义的升高。AAT最高水平出现在有结节性红斑的LL患者中（平均500.8±93.44mg/dl，P<0.001）。