Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No. 127 Dongming Road, Zhengzhou, 450008, China.
College of Medicine, Xi'an International University, Xi'an, 710077, China.
Sci Rep. 2024 Oct 10;14(1):23678. doi: 10.1038/s41598-024-75252-0.
Inflammation plays a crucial role in cancer development. The neutrophil-to-lymphocyte ratio (NLR), a measure of inflammation, is obtained from a complete blood count. However, little is known about the association between NLR and cancer in the general adult population in the United States. This study aimed to evaluate whether NLR is associated with cancer in American adults. This retrospective cross-sectional study included 28,016 adult participants from the National Health and Nutrition Examination Survey (NHANES) dataset spanning 2005 to 2018. Data on demographics (age, sex, race, marital status, Poverty-Income Ratio, education level), lifestyle factors (smoking, alcohol consumption, body mass index), medical conditions (hypertension, diabetes, cardiovascular disease), and laboratory parameters (hemoglobin, platelet count, alanine aminotransferase, creatinine, albumin, and lactate dehydrogenase), were collected. Logistic regression analysis was used to investigate the research objectives. Of the total 28,016 participants, 2639 had cancer. The mean age was 49.6 ± 17.6 years, and 50% were male. A positive association between NLR and cancer risk was observed after multivariate adjustment (OR = 1.20, 95% confidence interval (CI) = 1.05-1.36, p = 0.006). Similar patterns were observed in subgroup analyses (all p-values for interaction > 0.05). A higher NLR was directly correlated with an increased risk of developing cancer in adults.
炎症在癌症发展中起着至关重要的作用。中性粒细胞与淋巴细胞比值（NLR）是一种炎症指标，可以通过全血细胞计数获得。然而，在美国一般成年人群中，NLR 与癌症之间的关联知之甚少。本研究旨在评估 NLR 是否与美国成年人的癌症有关。
这项回顾性横断面研究纳入了来自 2005 年至 2018 年国家健康和营养检查调查（NHANES）数据集的 28016 名成年参与者。数据包括人口统计学特征（年龄、性别、种族、婚姻状况、贫困收入比、教育水平）、生活方式因素（吸烟、饮酒、体重指数）、医疗状况（高血压、糖尿病、心血管疾病）和实验室参数（血红蛋白、血小板计数、丙氨酸氨基转移酶、肌酐、白蛋白和乳酸脱氢酶）。采用 logistic 回归分析来研究研究目标。
在总共 28016 名参与者中，有 2639 人患有癌症。平均年龄为 49.6±17.6 岁，50%为男性。多变量调整后，NLR 与癌症风险呈正相关（OR=1.20，95%置信区间（CI）=1.05-1.36，p=0.006）。亚组分析也观察到了类似的模式（所有交互作用的 p 值均>0.05）。较高的 NLR 与成年人癌症风险的增加直接相关。
