Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
BMC Urol. 2024 Sep 6;24(1):194. doi: 10.1186/s12894-024-01569-7.
We conducted this study to summarize the results of studies reporting the role of NLR (neutrophil to lymphocyte ratio) in PSCC (penile squamous cell carcinoma).
This meta-analysis was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. A systematic search was conducted on PubMed, Scopus, and web of science up to March 10, 2023. Fourteen studies were included in the review. The NOS (Newcastle-Ottawa Scale) was used to determine the quality of the included studies. This meta-analysis was conducted on the studies reporting the relationship between NLR and survival using HR (hazard ratio) and 95% CI (confidence interval).
There was a significant association between NLR levels and the prognosis, nodal stage, and anatomical tumor stage of PSCC patients. In the meta-analysis of the association of NLR with survival, NLR level was significantly associated with lower cancer-specific survival (HR = 3.51, 95% CI = 2.07-5.98, p < 0.001) and lower disease-free survival (HR = 2.88, 95% CI = 1.60-5.20, p < 0.001). However, NLR was found to have no association with the stage, grade, location, and size of the tumor.
NLR has a significant diagnostic and prognostic value in PSCC.
我们进行这项研究，旨在总结报告中性粒细胞与淋巴细胞比值（NLR）在阴茎鳞状细胞癌（PSCC）中作用的研究结果。
本荟萃分析采用 PRISMA（系统评价和荟萃分析的首选报告项目）标准进行。截至 2023 年 3 月 10 日，我们在 PubMed、Scopus 和 web of science 上进行了系统搜索。共有 14 项研究纳入综述。我们使用 NOS（纽卡斯尔-渥太华量表）来确定纳入研究的质量。本荟萃分析对报告 NLR 与生存关系的研究进行了分析，使用 HR（风险比）和 95%CI（置信区间）。
NLR 水平与 PSCC 患者的预后、淋巴结分期和解剖肿瘤分期之间存在显著相关性。在 NLR 与生存关联的荟萃分析中，NLR 水平与较低的癌症特异性生存率（HR=3.51，95%CI=2.07-5.98，p<0.001）和较低的无病生存率（HR=2.88，95%CI=1.60-5.20，p<0.001）显著相关。然而，NLR 与肿瘤的分期、分级、位置和大小无关。
NLR 在 PSCC 中具有显著的诊断和预后价值。
