Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.
BMC Urol. 2024 Oct 10;24(1):222. doi: 10.1186/s12894-024-01613-6.
The dysregulation of sialylation plays a pivotal role in cancer progression and metastasis, impacting various aspects of tumor behavior. This study aimed to investigate the prognostic significance of long non-coding RNAs (lncRNAs) in relation to sialylation. Additionally, we aimed to develop a signature of sialylation-related lncRNAs in the context of bladder cancer.
This study used transcriptomic data and clinical information from the TCGA (the Cancer Genome Atlas) database to screen for sialylation-related lncRNAs and constructed a prognostic model. The relationships between these lncRNAs and biological pathways, immune cell infiltration, drug sensitivity, etc., were analyzed, and the expression of some lncRNAs was validated at the cellular level.
This study identified 6 prognostic lncRNAs related to sialylation and constructed a risk score model with high predictive accuracy and reliability. The survival period of patients in the high-risk group was significantly lower than that of the low-risk group, and it was related to various biological pathways and immune functions. In addition, this study found differences in the sensitivity of patients in different risk groups to chemotherapy drugs, providing a reference for personalized treatment.
In this study, we examined the relationship between sialylation-related lncRNA and the prognosis of bladder cancer, providing new molecular markers and potential targets for diagnosis and treatment. Our research revealed correlations between sialylation-related lncRNA characteristics and clinicopathological features, potential mechanisms, somatic mutations, immune microenvironment, chemotherapy response, and predicted drug sensitivity in bladder cancer. Additionally, in vitro cellular studies were conducted to validate these findings and lay the groundwork for future clinical applications.
唾液酸化的失调在癌症的进展和转移中起着关键作用，影响肿瘤行为的各个方面。本研究旨在探讨长链非编码 RNA（lncRNA）与唾液酸化相关的预后意义。此外，我们旨在建立膀胱癌中与唾液酸化相关的 lncRNA 特征。
本研究使用来自 TCGA（癌症基因组图谱）数据库的转录组数据和临床信息筛选与唾液酸化相关的 lncRNA，并构建预后模型。分析这些 lncRNA 与生物途径、免疫细胞浸润、药物敏感性等的关系，并在细胞水平验证一些 lncRNA 的表达。
本研究鉴定出 6 个与唾液酸化相关的预后 lncRNA，并构建了具有高预测准确性和可靠性的风险评分模型。高风险组患者的生存期明显低于低风险组，且与各种生物途径和免疫功能有关。此外，本研究还发现不同风险组患者对化疗药物的敏感性存在差异，为个体化治疗提供了参考。
在本研究中，我们研究了与唾液酸化相关的 lncRNA 与膀胱癌预后之间的关系，为诊断和治疗提供了新的分子标志物和潜在靶点。我们的研究揭示了与唾液酸化相关的 lncRNA 特征与膀胱癌临床病理特征、潜在机制、体细胞突变、免疫微环境、化疗反应和预测药物敏感性之间的相关性。此外，还进行了体外细胞研究来验证这些发现，并为未来的临床应用奠定了基础。
