Antal M
Acta Morphol Hung. 1985;33(1-2):13-9.
The effect of methohexital on retinal ultrastructure was studied. In spite of the negligible decrease in arterial blood pressure and the significant decrease in intraocular pressure, retinal cells showed hypoxic alterations after anaesthesia. This indicates that the protective effect of barbiturates against brain hypoxia fails to manifest in the retina. Therefore, in ophthalmological patients, application of methohexital without O2 inhalation and respiratory stimulation, is not recommended. Numerous reports have been published on the ophthalmological complications of anaesthesia. These were thought to be due to hypoxic cerebral lesions. In our previous studies almost all intravenously applied anaesthetics were found to produce fine structural changes in the retina which appeared to be independent of the general effect. As barbiturates are the most frequently used intravenous anaesthetics, the effects of these compounds have been studies. This paper is an account of retinal alterations observed after the application of methohexital, an anaesthetic of ultrashort action.
研究了美索比妥对视网膜超微结构的影响。尽管动脉血压仅有可忽略不计的下降，眼内压有显著下降，但麻醉后视网膜细胞仍出现缺氧改变。这表明巴比妥类药物对脑缺氧的保护作用在视网膜中未能显现。因此，对于眼科患者，不建议在不吸入氧气和无呼吸刺激的情况下应用美索比妥。关于麻醉的眼科并发症已经发表了许多报告。这些被认为是由于缺氧性脑损伤所致。在我们之前的研究中，几乎所有静脉应用的麻醉剂都被发现会在视网膜产生细微的结构变化，这些变化似乎与全身作用无关。由于巴比妥类药物是最常用的静脉麻醉剂，因此对这些化合物的作用进行了研究。本文报道了应用超短效麻醉剂美索比妥后观察到的视网膜改变。
