Czeizel A, Karig G
Acta Morphol Hung. 1985;33(1-2):89-99.
The birth prevalence of neural tube defects had a significant decrease in Hungary from the sixties till 1978. After this a slight but not significant increase was registered. The changing pattern had no correlation with the developmental (different groups of neural tube defects, still- and livebirth rate, sex ratio, birth weight distribution and twin rate), demographic (monthly and territorial distribution, maternal age, birth order) and medical (prevention program, genetic counselling) factors. There was only one obvious finding, a negative correlation with the standard of living of the population.
从60年代到1978年，匈牙利神经管缺陷的出生患病率显著下降。在此之后，出现了轻微但不显著的上升。这种变化模式与发育因素（不同类型的神经管缺陷、死产率和活产率、性别比、出生体重分布和双胎率）、人口统计学因素（月度和地域分布、产妇年龄、产次）以及医学因素（预防计划、遗传咨询）均无关联。唯一明显的发现是，它与人口的生活水平呈负相关。
