Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Shanghai East Clinical Medical College, Nanjing Medical University, Nanjing, China.
Front Immunol. 2024 Sep 26;15:1444253. doi: 10.3389/fimmu.2024.1444253. eCollection 2024.
Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.
液-液相分离（LLPS）是各种生物过程的重要组成部分，通过创建一个浓缩的、无膜的环境来促进信号转导，在各种生理和病理过程中起着至关重要的作用。最近的证据强调了 LLPS 在人类健康和疾病中的重要性。然而，其在呼吸疾病中的意义仍知之甚少。本综述探讨了目前对 LLPS 机制和生物学作用的认识，特别关注其与呼吸疾病的相关性，旨在加深我们的理解，并为在这方面研究相分离提出一个新的范例。
