Augmented reality (AR) is emerging as a key technology in neurosurgery. Projecting three-dimensional (3D) anatomic models onto the surgical field provides unique operative information to make procedures safer and more efficient. A small footprint, rapid registration AR system was used for bedside guidance during aspiration of a subdural hygroma. A 77-year-old male presented for resection of a suprasellar tumor and subsequently developed a large bilateral subdural hygroma. We performed the aspiration of the hygroma at the bedside using AR guidance. The AR system allowed for precise needle placement during the aspiration. The aim of this report was to demonstrate the clinical feasibility of integrating a novel AR system into the clinical workflow of a bedside procedure. As AR continues to expand in the field, the benefits of this technology for various procedures will become more evident.