Qiu Haoyi, Nazarenus Jakob, Egeler Bernhard, Thode Tom, Osman Firdaws, Osmonov Daniar, Bahr Jörg, Kaps Sören, Siebert Frank-Andre, Koch Reinhard, Lützen Ulf, Adelung Rainer, Siebert Leonard
Functional Nanomaterials, Department of Materials Science, Kiel University, 24143 Kiel, Germany.
Multimedia Information Processing, Institute for Computer Science, Kiel University, 24118 Kiel, Germany.
ACS Mater Lett. 2024 Sep 26;6(10):4847-4853. doi: 10.1021/acsmaterialslett.4c01660. eCollection 2024 Oct 7.
Medical phantoms mimic aspects of procedures like computed tomography (CT), ultrasound (US) imaging, and surgical practices. However, the materials for current commercial phantoms are expensive and the fabrication with these is complex and lacks versatility. Therefore, existing material solutions are not suitable for creating patient-specific phantoms. We present a novel and cost-effective material system (utilizing ubiquitous sodium alginate hydrogel and coconut fat) with independently and accurately tailorable CT, US, and mechanical properties. By varying the concentration of alginate, cross-linker, and coconut fat, the radiological parameters and the elastic modulus were adjusted independently in a wide range. The independence was demonstrated by creating phantoms with features hidden in US, while visible in CT imaging and vice versa. This system is particularly beneficial in resource-scarce areas since the materials are cheap (<$ 1 USD/kg) and easy to obtain, offering realistic and versatile phantoms to practice surgeries and ultimately enhance patient care.
医学模型模仿诸如计算机断层扫描（CT）、超声（US）成像和外科手术等操作的各个方面。然而，当前商业模型所使用的材料昂贵，并且用这些材料制造复杂且缺乏通用性。因此，现有的材料解决方案不适用于创建针对特定患者的模型。我们提出了一种新颖且具有成本效益的材料系统（利用常见的海藻酸钠水凝胶和椰子油），其具有可独立且精确调整的CT、US和机械性能。通过改变海藻酸钠、交联剂和椰子油的浓度，可在很宽的范围内独立调整放射学参数和弹性模量。通过创建在US中隐藏特征而在CT成像中可见，反之亦然的模型，证明了这种独立性。该系统在资源稀缺地区特别有益，因为材料便宜（<1美元/千克）且易于获取，可提供逼真且通用的模型用于练习手术，并最终改善患者护理。
