Mackle Eleanor C, Shapey Jonathan, Maneas Efthymios, Saeed Shakeel R, Bradford Robert, Ourselin Sebastien, Vercauteren Tom, Desjardins Adrien E
Wellcome / EPSRC Centre for Interventional and Surgical Sciences, University College London; Department of Medical Physics and Biomedical Engineering, University College London;
Wellcome / EPSRC Centre for Interventional and Surgical Sciences, University College London; Department of Medical Physics and Biomedical Engineering, University College London; Department of Neurosurgery, National Hospital for Neurology and Neurosurgery; School of Biomedical Engineering & Imaging Sciences, King's College London.
J Vis Exp. 2020 Jul 14(161). doi: 10.3791/61344.
Phantoms are essential tools for clinical training, surgical planning and the development of novel medical devices. However, it is challenging to create anatomically accurate head phantoms with realistic brain imaging properties because standard fabrication methods are not optimized to replicate any patient-specific anatomical detail and 3D printing materials are not optimized for imaging properties. In order to test and validate a novel navigation system for use during brain tumor surgery, an anatomically accurate phantom with realistic imaging and mechanical properties was required. Therefore, a phantom was developed using real patient data as input and 3D printing of molds to fabricate a patient-specific head phantom comprising the skull, brain and tumor with both ultrasound and X-ray contrast. The phantom also had mechanical properties that allowed the phantom tissue to be manipulated in a similar manner to how human brain tissue is handled during surgery. The phantom was successfully tested during a surgical simulation in a virtual operating room. The phantom fabrication method uses commercially available materials and is easy to reproduce. The 3D printing files can be readily shared, and the technique can be adapted to encompass many different types of tumor.
体模是临床培训、手术规划和新型医疗设备开发的重要工具。然而，创建具有逼真脑成像特性的解剖学精确头部体模具有挑战性，因为标准制造方法未针对复制任何患者特定的解剖细节进行优化，并且3D打印材料也未针对成像特性进行优化。为了测试和验证一种用于脑肿瘤手术的新型导航系统，需要一个具有逼真成像和机械特性的解剖学精确体模。因此，开发了一种体模，使用真实患者数据作为输入，并通过3D打印模具来制造一个患者特定的头部体模，该体模包括颅骨、大脑和具有超声和X射线造影剂的肿瘤。该体模还具有机械特性，使得体模组织能够以与手术中处理人脑组织类似的方式进行操作。该体模在虚拟手术室的手术模拟中成功进行了测试。体模制造方法使用市售材料且易于复制。3D打印文件可以很容易地共享，并且该技术可以适用于涵盖许多不同类型的肿瘤。
