Enteropathy-Associated T-Cell Lymphoma Treated With Autologous Hematopoietic Stem-Cell Transplant: A Glimmer of Hope?

We report a case of primary enteropathy-associated T-cell lymphoma in a 50-year-old man presenting with abdominal pain, chronic diarrhea, and significant weight loss over 6 months. Diagnosis was confirmed through endoscopy, biopsy, and positron emission tomography-computed tomography, staging the disease as stage 1E. The patient underwent initial treatment with the cyclophosphamide, doxorubicin (also known as hydroxydaunorubicin), vincristine (also known as oncovin), etoposide, and prednisolone chemotherapy regimen, followed by high-dose hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone chemotherapy and autologous stem cell transplantation. Despite developing febrile neutropenia and septic shock during treatment, the patient achieved disease remission and symptom resolution. This case underscores the potential of autologous stem-cell transplantation as a curative approach for primary enteropathy-associated T-cell lymphoma and highlights the need for further research on its effectiveness.