Gahra Amrit, Katrevula Anudeep, Sekaran Anuradha, Wanve Balasaheb, Reddy Katukuri Goutham, Lakhtakia Sundeep, Duvvur Nageshwar Reddy
Medical Gastroenterology, AIG Hospitals, Hyderabad, Telangana, India.
Pathology, AIG Hospitals, Hyderabad, Telangana, India.
ACG Case Rep J. 2024 Oct 10;11(10):e01529. doi: 10.14309/crj.0000000000001529. eCollection 2024 Oct.
We report a case of primary enteropathy-associated T-cell lymphoma in a 50-year-old man presenting with abdominal pain, chronic diarrhea, and significant weight loss over 6 months. Diagnosis was confirmed through endoscopy, biopsy, and positron emission tomography-computed tomography, staging the disease as stage 1E. The patient underwent initial treatment with the cyclophosphamide, doxorubicin (also known as hydroxydaunorubicin), vincristine (also known as oncovin), etoposide, and prednisolone chemotherapy regimen, followed by high-dose hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone chemotherapy and autologous stem cell transplantation. Despite developing febrile neutropenia and septic shock during treatment, the patient achieved disease remission and symptom resolution. This case underscores the potential of autologous stem-cell transplantation as a curative approach for primary enteropathy-associated T-cell lymphoma and highlights the need for further research on its effectiveness.
我们报告了一例50岁男性原发性肠病相关T细胞淋巴瘤病例，该患者出现腹痛、慢性腹泻，并在6个月内体重显著减轻。通过内镜检查、活检和正电子发射断层扫描-计算机断层扫描确诊，疾病分期为1E期。患者首先接受了环磷酰胺、阿霉素（也称为羟基柔红霉素）、长春新碱（也称为安可平）、依托泊苷和泼尼松龙化疗方案，随后接受了高剂量超分割环磷酰胺、长春新碱、阿霉素和地塞米松化疗以及自体干细胞移植。尽管在治疗期间出现了发热性中性粒细胞减少和感染性休克，但患者实现了疾病缓解和症状消退。该病例强调了自体干细胞移植作为原发性肠病相关T细胞淋巴瘤治愈方法的潜力，并突出了对其有效性进行进一步研究的必要性。
