Geocze S, Nader H B, Mincis M, Novo N F, Paiva E R
Braz J Med Biol Res. 1985;18(4):487-92.
The sulfated glycosaminoglycan (SGAG) composition of gastric mucosa from 24 patients with chronic superficial gastritis, 2 patients with adenocarcinoma and 36 normal subjects is reported. The mucosa was obtained by endoscopic biopsy and after histopathological examination the SGAG were extracted and characterized. Three different SGAG were isolated: chondroitin 4,6-sulfate, dermatan sulfate and heparan sulfate. Their relative concentrations for the different groups were submitted to analysis of variance by Scheffe's method. Different SGAG compositions were observed in two gastric regions (antrum and body), in chronic superficial gastritis, in adenocarcinoma and in two age groups (less than 40 years and greater than 40 years). These and other results suggest that these macromolecules might be involved in the processes of cell division and aging.
本文报道了24例慢性浅表性胃炎患者、2例腺癌患者及36例正常受试者胃黏膜的硫酸化糖胺聚糖（SGAG）组成情况。通过内镜活检获取黏膜组织，经组织病理学检查后提取并鉴定SGAG。分离出三种不同的SGAG：硫酸软骨素4,6-硫酸盐、硫酸皮肤素和硫酸乙酰肝素。采用谢费法对不同组别的相对浓度进行方差分析。在胃的两个区域（胃窦和胃体）、慢性浅表性胃炎、腺癌以及两个年龄组（小于40岁和大于40岁）中观察到不同的SGAG组成。这些及其他结果表明，这些大分子可能参与细胞分裂和衰老过程。
