Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
Department of Chemistry, Stella Maris College, Affiliated to the University of Madras, Chennai, Tamil Nadu 600086, India.
Inorg Chem. 2024 Oct 28;63(43):20705-20713. doi: 10.1021/acs.inorgchem.4c03383. Epub 2024 Oct 11.
The anti-viral drug hydroxychloroquine (HCQ) has captivated significant interest in the pharmaceutical field, as it is a quinolone derivative. Its unrestrained occurrence causes prominent health hazards owing to its persistent, carcinogenic, recalcitrant, and teratogenic nature. Herein, in this work, an experimental investigation was carried out toward the photocatalytic degradation of HCQ drug using magnesium zirconate (MgZrO) nanoparticles as an effective photocatalyst. A comprehensive characterizations of the as-synthesized material was carried out. The photocatalytic degradation of the HCQ drug was examined with various sources of light energies. The obtained outcomes indicated that ±85% of HCQ was degraded using a MgZrO photocatalyst within 30 min of the reaction time under UV-visible (ultraviolet) light irradiation. Further, other significant operational parameters such as various catalyst dosages, HCQ concentrations, pH, scavengers, and salts were examined. The degradation studies revealed that the reaction followed pseudo-first-order kinetics. Hence, this perovskite-type MgZrO has grasped profound attention in environmental remediation, significantly in photocatalytic degradation of HCQ drug. This comprehensive research offers green synthesis strategy as a substantial framework for providing effective photocatalyst that addresses contemporary water pollution issues linked to notable results. This aids in targeting era-driven advancements toward a clean and safe future environment.
抗疟药物羟氯喹（HCQ）作为一种喹诺酮衍生物，在制药领域引起了极大的关注。由于其持续存在、致癌、顽固和致畸的特性，它的大量存在会造成严重的健康危害。在这项工作中，我们使用镁锆酸盐（MgZrO）纳米粒子作为一种有效的光催化剂，对 HCQ 药物的光催化降解进行了实验研究。对合成材料进行了全面的特性分析。用各种光源研究了 HCQ 药物的光催化降解。结果表明，在紫外-可见（紫外线）光照射下，反应 30 分钟内，使用 MgZrO 光催化剂可将 HCQ 降解约 85%。此外，还研究了其他重要的操作参数，如各种催化剂剂量、HCQ 浓度、pH 值、清除剂和盐。降解研究表明，反应遵循准一级动力学。因此，这种钙钛矿型 MgZrO 在环境修复中引起了广泛关注，特别是在 HCQ 药物的光催化降解方面。这项综合研究提供了一种绿色合成策略，为提供有效的光催化剂提供了一个实质性的框架，以解决与显著结果相关的当代水污染问题。这有助于针对时代驱动的发展，朝着清洁和安全的未来环境迈进。
