Department of Small Animal Clinical Sciences, Veterinary and Comparative Neuro-oncology Laboratory, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duckpond Drive, Blacksburg, VA 24061, USA.
Vet Clin North Am Small Anim Pract. 2025 Jan;55(1):81-94. doi: 10.1016/j.cvsm.2024.07.008. Epub 2024 Oct 11.
The blood-brain barrier and knowledge gaps in tumor biology remain significant obstacles to the development of effective treatments for brain tumors. The identification of shared molecular and genetic pathways that contribute to tumorigenesis in both dogs and people has been key to the discovery and translation of targeted pharmacologic and biologic therapies. Treatment approaches often utilize targeted or multifunctional antitumor agents, such as nanocarriers, molecularly targeted agents, immunotherapeutics, and oncolytic viruses in combination with alternative therapeutic delivery strategies. The article discusses about various treatments albeit none of the treatments discussed here are widely available or approved for clinical use.
血脑屏障和肿瘤生物学方面的知识空白仍然是开发脑肿瘤有效治疗方法的重大障碍。确定在狗和人身上都有助于肿瘤发生的共同分子和遗传途径是发现和转化靶向药物和生物疗法的关键。治疗方法通常利用靶向或多功能抗肿瘤药物，如纳米载体、分子靶向药物、免疫疗法和溶瘤病毒，并结合其他治疗方法。本文讨论了各种治疗方法，但这里讨论的治疗方法都没有广泛应用或批准用于临床。
